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Neuronal vacuolation in young Rottweiler dogs.
- Source :
-
Acta neuropathologica [Acta Neuropathol] 1999 Feb; Vol. 97 (2), pp. 192-5. - Publication Year :
- 1999
-
Abstract
- Neuronal vacuolation, involving the cerebellar roof nuclei, Purkinje cells, selected nuclei of the brain stem, thalamus, Clarke's column, anterior and posterior horns of the spinal cord, visceral autonomic ganglia and myenteric plexus, as well as axonal degeneration of the white matter of the brain stem, cerebellar pedunculi, dorsolateral columns of the spinal cord and ventral roots of the spinal cord, were observed in two young Rottweiler dogs which were clinically afflicted with hind limb weakness progressing to paraparesia, ataxia, intention tremor, and difficulty in swallowing and barking. The absence of modifications in Bcl-2 and Bax immunoreactivity, a lack of strong c-Jun/AP-1 (N) immunoreactivity in vacuolated cells, and the absence of DNA breaks, as seen with the method of in situ end-labeling of nuclear DNA fragmentation, all suggest that there is no involvement of the apoptotic pathway in vacuolated cells in this new neurodegenerative disorder.
- Subjects :
- Animals
Brain metabolism
Brain pathology
Dog Diseases metabolism
Dogs
Female
Immunohistochemistry
In Situ Nick-End Labeling
Male
Neurodegenerative Diseases metabolism
Neurodegenerative Diseases pathology
Neurons metabolism
Proto-Oncogene Proteins metabolism
Proto-Oncogene Proteins c-bcl-2 metabolism
Proto-Oncogene Proteins c-jun metabolism
Spinal Cord metabolism
Spinal Cord pathology
Transcription Factor AP-1 metabolism
bcl-2-Associated X Protein
Dog Diseases pathology
Neurodegenerative Diseases veterinary
Neurons pathology
Vacuoles pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0001-6322
- Volume :
- 97
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Acta neuropathologica
- Publication Type :
- Academic Journal
- Accession number :
- 9928831
- Full Text :
- https://doi.org/10.1007/s004010050973