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Herpes simplex virus vaccine in recurrent herpetic ocular infection.
- Source :
-
Cornea [Cornea] 1999 Jan; Vol. 18 (1), pp. 47-51. - Publication Year :
- 1999
-
Abstract
- Purpose: To evaluate the efficacy of an antiherpetic vaccine in recurrent herpetic ocular infections.<br />Methods: Twenty patients with herpes simplex virus 1-related recurrent keratitis/keratouveitis were prospectively enrolled and randomly assigned to receive either a specific vaccination with heat shock-inactivated herpes simplex virus type 1 (10 patients) or to be observed as controls (10 patients). The number, duration, and anatomic localization of relapses were recorded in all the patients for 12 months before inclusion in the study and for a similar period after the assignment of each subject to vaccine or control group.<br />Results: In the vaccine group, we observed a reduction both in the number (p = 0.016) and average duration (p = 0.050) of recurrences, whereas in the control group, no significant change was found comparing a 12-month period before and after inclusion in the study. The comparison between the two groups highlighted a significant reduction in the number (p = 0.013) and average duration (p = 0.051) of relapses in treated subjects, who did not show any significant vaccine-induced side effects.<br />Conclusion: The use of a vaccination with heat shock-inactivated herpes simplex virus 1 seems to be able to reduce the number and duration of relapses in herpes simplex virus 1-related keratitis/keratouveitis.
- Subjects :
- Adolescent
Adult
Aged
Antibodies, Viral analysis
Child
Cornea pathology
Cornea virology
DNA, Viral analysis
Female
Follow-Up Studies
Humans
Keratitis, Herpetic immunology
Male
Middle Aged
Prospective Studies
Recurrence
Treatment Outcome
Uveitis, Anterior immunology
Uveitis, Anterior prevention & control
Vaccination
Herpesvirus 1, Human immunology
Keratitis, Herpetic prevention & control
Viral Vaccines administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0277-3740
- Volume :
- 18
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cornea
- Publication Type :
- Academic Journal
- Accession number :
- 9894936