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Mitochondrial dynamics in yeast.
- Source :
-
Annual review of cell and developmental biology [Annu Rev Cell Dev Biol] 1998; Vol. 14, pp. 265-303. - Publication Year :
- 1998
-
Abstract
- Proteins that control mitochondrial dynamics in yeast are being identified at a rapid pace. These proteins include cytoskeletal elements that regulate organelle distribution and inheritance and several outer membrane proteins that are required to maintain the branched, mitochondrial reticulum. Interestingly, three of the high molecular weight GTPases encoded by the yeast genome are required for mitochondrial integrity and are potential regulators of mitochondrial branching, distribution, and membrane fusion. The recent finding that mtDNA mixing is restricted in the mitochondrial matrix has stimulated the hunt for the molecular machinery that anchors mitochondrial nucleoids in the organelle. Considering that many aspects of mitochondrial structure and behavior are strikingly similar in different cell types, the functional analyses of these yeast proteins should provide general insights into the mechanisms governing mitochondrial dynamics in all eukaryotes.
- Subjects :
- Cell Cycle
Cell Nucleus physiology
Cytoskeleton physiology
DNA, Fungal genetics
DNA, Fungal metabolism
DNA, Mitochondrial genetics
DNA, Mitochondrial metabolism
GTP Phosphohydrolases genetics
GTP Phosphohydrolases metabolism
Genome, Fungal
Intracellular Membranes physiology
Membrane Fusion
Mitochondria genetics
Mitochondria ultrastructure
Saccharomyces cerevisiae genetics
Saccharomyces cerevisiae ultrastructure
Mitochondria physiology
Saccharomyces cerevisiae physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1081-0706
- Volume :
- 14
- Database :
- MEDLINE
- Journal :
- Annual review of cell and developmental biology
- Publication Type :
- Academic Journal
- Accession number :
- 9891785
- Full Text :
- https://doi.org/10.1146/annurev.cellbio.14.1.265