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Cathepsin-D in primary breast cancer: prognostic evaluation involving 2810 patients.
- Source :
-
British journal of cancer [Br J Cancer] 1999 Jan; Vol. 79 (2), pp. 300-7. - Publication Year :
- 1999
-
Abstract
- There is controversy regarding the prognostic value of cathepsin-D in primary breast cancer. An increased level of cathepsin-D in tumour extracts has been found to be associated with a poor relapse-free and overall survival. Studies performed with immunohistochemistry or Western blotting have produced diverse results. We have analysed 2810 cytosolic extracts obtained from human primary breast tumours for cathepsin-D expression, and have correlated their levels with prognosis. The median follow-up of the patients still alive was 88 months. Patients with high cathepsin-D levels had a significantly worse relapse-free and overall survival, also in multivariate analysis (P < 0.0001). Adjuvant therapy which was associated with an improved prognosis in node-positive patients in univariate analysis, also significantly added to the multivariate models for relapse-free and overall survival. There were no statistically significant interactions between the levels of cathepsin-D and any of the classical prognostic factors in analysis for relapse-free survival, suggesting that the prognostic value of cathepsin-D is not different in the various subgroups of patients. Indeed, multivariate analyses in subgroups of node-negative and -positive patients, pre- and post-menopausal patients, and their combinations, showed that tumours with high cathepsin-D values had a significantly poor relapse-free survival, with relative hazard rates ranging from 1.3 to 1.5, compared with tumours with low cathepsin-D levels. The results presented here on 2810 patients confirm that high cytosolic cathepsin-D values are associated with poor prognosis in human primary breast cancer.
- Subjects :
- Adult
Aged
Aged, 80 and over
Analysis of Variance
Breast Neoplasms chemistry
Breast Neoplasms mortality
Breast Neoplasms pathology
Disease-Free Survival
Female
Humans
Middle Aged
Prognosis
Receptors, Estrogen analysis
Receptors, Progesterone analysis
Recurrence
Regression Analysis
Breast Neoplasms enzymology
Cathepsin D metabolism
Cytosol enzymology
Neoplasm Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0007-0920
- Volume :
- 79
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- British journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 9888472
- Full Text :
- https://doi.org/10.1038/sj.bjc.6690048