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A case of Cushing's syndrome due to ACTH-independent bilateral macronodular hyperplasia associated with excessive secretion of mineralocorticoids.
- Source :
-
Endocrine journal [Endocr J] 1998 Aug; Vol. 45 (4), pp. 485-91. - Publication Year :
- 1998
-
Abstract
- A 74-year-old man developed Cushing's syndrome and hypokalemia due to ACTH-independent bilateral macronodular adrenocortical hyperplasia (AIMAH) with excessive secretion of mineralocorticoid hormones. Plasma concentrations of weak mineralocorticoids were high. The increase in plasma cortisol did not have a diurnal rhythm, and was not suppressed by a high dose of dexamethasone. Plasma ACTH was undetectable, but plasma cortisol was increased by ACTH administration. The concentrations of mineralocorticoids, especially deoxycorticosterone and corticosterone were increased, and augmented the response to ACTH administration. Plasma renin activity and aldosterone concentrations were rather suppressed. Both adrenal glands, with a total weight of 110 g, were enlarged and contained several macronodules. These nodules were composed of hyperplasia of small cortical cells and usual clear cells. This is a rare case of ACTH-independent bilateral macronodular adrenocortical hyperplasia because there were excessive secretion of mineralocorticoid and hypokalemia.
- Subjects :
- Adrenal Cortex metabolism
Aged
Aldosterone blood
Cushing Syndrome diagnosis
Dexamethasone
Glucocorticoids
Humans
Hydrocortisone blood
Hyperplasia blood
Hyperplasia drug therapy
Male
Metyrapone
Radioimmunoassay
Renin blood
Adrenal Cortex pathology
Adrenocorticotropic Hormone
Cushing Syndrome pathology
Mineralocorticoids metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0918-8959
- Volume :
- 45
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Endocrine journal
- Publication Type :
- Academic Journal
- Accession number :
- 9881897
- Full Text :
- https://doi.org/10.1507/endocrj.45.485