Back to Search
Start Over
Development of new chromanol antagonists of leukotriene D4.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1998 Jul 21; Vol. 8 (14), pp. 1791-6. - Publication Year :
- 1998
-
Abstract
- By addressing the issues of potency and metabolism in 3, a new series of LTD4 antagonists represented by (+)-26 was developed which is equipotent to clinical LTD4 antagonists Zafirlukast (1) and Pranlukast (2).
- Subjects :
- Animals
Chromans metabolism
Chromones pharmacology
Guinea Pigs
Humans
Indoles
Leukotriene Antagonists metabolism
Leukotriene D4 metabolism
Phenylcarbamates
Protein Binding
Sulfonamides
Tosyl Compounds pharmacology
Chromans chemistry
Chromans pharmacology
Leukotriene Antagonists chemistry
Leukotriene Antagonists pharmacology
Leukotriene D4 antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 8
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 9873435
- Full Text :
- https://doi.org/10.1016/s0960-894x(98)00273-x