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The synthesis and evaluation of cyclic ureas as HIV protease inhibitors: modifications of the P1/P1' residues.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1998 Apr 07; Vol. 8 (7), pp. 823-8. - Publication Year :
- 1998
-
Abstract
- Two series of cyclic ureas modified at the P1/P1' residue were prepared and evaluated for HIV protease inhibition and whole cell antiviral activity. Compounds 8b, 10 (3- and 4-pyridylmethyl analogs) and 6b (4-methoxy analog) showed significant improvement in antiviral activity relative to lead compounds DMP323 and DMP 450.
- Subjects :
- Antiviral Agents chemistry
Antiviral Agents pharmacology
Azepines pharmacology
HIV drug effects
HIV Protease metabolism
HIV Protease Inhibitors chemistry
HIV Protease Inhibitors pharmacology
Indicators and Reagents
Kinetics
Molecular Structure
Structure-Activity Relationship
Urea chemistry
Urea pharmacology
Antiviral Agents chemical synthesis
HIV Protease Inhibitors chemical synthesis
Urea analogs & derivatives
Urea chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 8
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 9871548
- Full Text :
- https://doi.org/10.1016/s0960-894x(98)00119-x