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Human chorionic gonadotropin as a target for cancer vaccines.
- Source :
-
Oncology reports [Oncol Rep] 1999 Jan-Feb; Vol. 6 (1), pp. 7-17. - Publication Year :
- 1999
-
Abstract
- Human chorionic gonadotropin (hCG) is expressed by common cancers and may play a role in cell transformation as well as angiogenic, metastatic, and immune escape phenomena that are central to cancer progression. Clinical trials with a vaccine targeting the carboxy-terminal peptide of -hCG have indicated that tolerance to this oncofetal antigen can be broken. Humoral responses that may modulate the biologic activity of tumor-associated hCG as well as cellular responses to hCG have been generated. Studies are in progress to further define the biologic significance of hCG in cancer and to develop a vaccine approach that will best target this expression.
- Subjects :
- Alleles
Animals
Cancer Vaccines adverse effects
Cancer Vaccines therapeutic use
Chorionic Gonadotropin physiology
Chorionic Gonadotropin therapeutic use
Chorionic Gonadotropin, beta Subunit, Human genetics
Chorionic Gonadotropin, beta Subunit, Human immunology
Clinical Trials as Topic
Contraception, Immunologic
Diphtheria Toxin therapeutic use
Female
Gene Expression Regulation, Neoplastic
Humans
Male
Mice
Neoplasm Proteins physiology
Neoplasms genetics
Neoplasms immunology
Neoplasms metabolism
Neoplasms, Experimental immunology
Neoplasms, Experimental therapy
Organ Specificity
Papio
Peptide Fragments immunology
Pregnancy
Rabbits
Recombinant Fusion Proteins
Th1 Cells immunology
Th2 Cells immunology
Vaccines, Synthetic therapeutic use
Cancer Vaccines immunology
Chorionic Gonadotropin immunology
Hormones, Ectopic immunology
Neoplasm Proteins immunology
Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1021-335X
- Volume :
- 6
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Oncology reports
- Publication Type :
- Academic Journal
- Accession number :
- 9864394