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Virus-specific CD8(+) T cell numbers are maintained during gamma-herpesvirus reactivation in CD4-deficient mice.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 1998 Dec 22; Vol. 95 (26), pp. 15565-70. - Publication Year :
- 1998
-
Abstract
- The murine gamma-herpesvirus 68 replicates in epithelial sites after intranasal challenge, then persists in various cell types, including B lymphocytes. Mice that lack CD4(+) T cells (I-Ab-/-) control the acute infection, but suffer an ultimately lethal recrudescence of lytic viral replication in the respiratory tract. The consequences of CD4(+) T cell deficiency for the generation and maintenance of murine gamma-herpesvirus 68-specific CD8(+) set now have been analyzed by direct staining with viral peptides bound to major histocompatibility complex class I tetramers and by a spectrum of functional assays. Both acutely and during viral reactivation, the CD8(+) T cell responses in the I-Ab-/- group were no less substantial than in the I-Ab+/+ controls. Indeed, virus-specific CD8(+) T cell numbers were increased in the lymphoid tissue of clinically compromised I-Ab-/- mice, although relatively few of the potential cytotoxic T lymphocyte effectors were recruited back to the site of pathology in the lung. Thus the viral reactivation that occurs in the absence of CD4(+) T cells was not associated with any exhaustion of the virus-specific cytotoxic T lymphocyte response. It seems that CD8(+) T cells alone are insufficient to maintain long-term control of this persistent gamma-herpesvirus.
- Subjects :
- Animals
Female
Histocompatibility Antigens Class I analysis
Histocompatibility Antigens Class II genetics
Histocompatibility Antigens Class II physiology
Lymph Nodes immunology
Lymphocyte Count
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Mutant Strains
Spleen immunology
Virus Activation
CD4-Positive T-Lymphocytes immunology
CD8-Positive T-Lymphocytes immunology
CD8-Positive T-Lymphocytes virology
Gammaherpesvirinae growth & development
Gammaherpesvirinae immunology
Genes, MHC Class II
Herpesviridae Infections immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0027-8424
- Volume :
- 95
- Issue :
- 26
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 9861009
- Full Text :
- https://doi.org/10.1073/pnas.95.26.15565