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Neonatal lupus erythematosus: maternal IgG antibodies bind to a recombinant NH2-terminal fusion protein encoded by human alpha-fodrin cDNA.
- Source :
-
The Journal of investigative dermatology [J Invest Dermatol] 1998 Dec; Vol. 111 (6), pp. 1189-92. - Publication Year :
- 1998
-
Abstract
- IgG antibodies to a cleavage product of alpha-fodrin (120 kDa alpha-fodrin) have recently been identified as organ-specific autoantibodies in primary Sjögren's syndrome. In this study, we examined seroreactivity of mothers and infants with neonatal lupus erythematosus (NLE) to a recombinant NH2-terminal protein (120 kDa alpha-fodrin) of human alpha-fodrin. Serum samples were collected during the perinatal period in seven pregnancies of five mothers delivering offspring with NLE. Anti-120 kDa alpha-fodrin antibodies were identified by immunoblotting in six of seven perinatal maternal sera of offspring with NLE: one of two congenital heart block offspring and all five offspring with cutaneous NLE. These antibodies were placentally transmitted to infants. One of the five mothers had primary Sjögren's syndrome, and four were asymptomatic. One asymptomatic mother did not demonstrate anti-120 kDa alpha-fodrin activity at the time of the first delivery of a congenital heart block infant, but was found to be positive at the time of subsequent delivery of a second child with cutaneous NLE. We propose that maternal antibodies to 120 kDa alpha-fodrin may be an additional serologic marker for the risk of NLE in anti-Ro/SS-A positive women.
- Subjects :
- Autoantibodies blood
Autoantigens isolation & purification
Binding Sites, Antibody
Carrier Proteins genetics
Carrier Proteins immunology
DNA, Complementary genetics
Female
Humans
Immunoglobulin G immunology
Infant, Newborn
Lupus Erythematosus, Cutaneous immunology
Microfilament Proteins genetics
Microfilament Proteins immunology
Mothers
Recombinant Proteins immunology
Sjogren's Syndrome immunology
Lupus Erythematosus, Systemic immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-202X
- Volume :
- 111
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of investigative dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 9856838
- Full Text :
- https://doi.org/10.1046/j.1523-1747.1998.00440.x