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Activity-dependent modulation of synaptic AMPA receptor accumulation.
- Source :
-
Neuron [Neuron] 1998 Nov; Vol. 21 (5), pp. 1067-78. - Publication Year :
- 1998
-
Abstract
- Both theoretical and experimental work have suggested that central neurons compensate for changes in excitatory synaptic input in order to maintain a relatively constant output. We report here that inhibition of excitatory synaptic transmission in cultured spinal neurons leads to an increase in mEPSC amplitudes, accompanied by an equivalent increase in the accumulation of AMPA receptors at synapses. Conversely, increasing excitatory synaptic activity leads to a decrease in synaptic AMPA receptors and a decline in mEPSC amplitude. The time course of this synaptic remodeling is slow, similar to the metabolic half-life of neuronal AMPA receptors. Moreover, inhibiting excitatory synaptic transmission significantly prolongs the half-life of the AMPA receptor subunit GluR1, suggesting that synaptic activity modulates the size of the mEPSC by regulating the turnover of postsynaptic AMPA receptors.
- Subjects :
- 2-Amino-5-phosphonovalerate pharmacology
6-Cyano-7-nitroquinoxaline-2,3-dione pharmacology
Animals
Cells, Cultured
Excitatory Postsynaptic Potentials drug effects
Excitatory Postsynaptic Potentials physiology
Half-Life
Kinetics
Picrotoxin pharmacology
Rats
Receptors, AMPA drug effects
Spinal Cord cytology
Strychnine pharmacology
Synaptic Transmission drug effects
Synaptic Transmission physiology
Receptors, AMPA metabolism
Receptors, AMPA physiology
Synapses metabolism
Synapses physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0896-6273
- Volume :
- 21
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Neuron
- Publication Type :
- Academic Journal
- Accession number :
- 9856462
- Full Text :
- https://doi.org/10.1016/s0896-6273(00)80624-8