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Familial Kaposi's sarcoma and Paget's disease of bone.
- Source :
-
The Australasian journal of dermatology [Australas J Dermatol] 1998 Nov; Vol. 39 (4), pp. 241-3. - Publication Year :
- 1998
-
Abstract
- Familial Kaposi's sarcoma and familial Paget's disease of bone have not previously been reported to occur in the one patient or the one family. We report on an 82-year-old female of Lebanese descent who was recently diagnosed with Kaposi's sarcoma and Paget's disease. Of the patient's eight siblings, seven had Paget's disease and two of these also had Kaposi's sarcoma. Histocompatibility leucocyte antigen (HLA) class I and II typing of the patient showed: A2, A3; B35, Bx; Bw6; Cw4; DR beta 1*1101 (an HLA-DR5 subtype), DR beta 3 and DQ beta 1*0301. Previous reports have described possible associations of familial Kaposi's sarcoma with HLA-DR5 and Paget's disease with DR2. DR beta 1*1104, DP beta 1*04 and DQw1. Genetic factors and possible viral aetiologies for each condition are reviewed.
- Subjects :
- Aged
Aged, 80 and over
Australia
Female
Genetic Predisposition to Disease
HLA-DR5 Antigen analysis
Histocompatibility Testing
Humans
Lebanon ethnology
Osteitis Deformans virology
Pedigree
Sarcoma, Kaposi virology
Skin Neoplasms virology
Toes
Osteitis Deformans genetics
Sarcoma, Kaposi genetics
Skin Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0004-8380
- Volume :
- 39
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Australasian journal of dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 9838721
- Full Text :
- https://doi.org/10.1111/j.1440-0960.1998.tb01481.x