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Mutational evidence for a common kappa antagonist binding pocket in the wild-type kappa and mutant mu[K303E] opioid receptors.
- Source :
-
Journal of medicinal chemistry [J Med Chem] 1998 Dec 03; Vol. 41 (25), pp. 4911-4. - Publication Year :
- 1998
- Subjects :
- Amino Acid Sequence
Animals
Binding, Competitive
COS Cells
Guanidines
Guinea Pigs
Ileum drug effects
In Vitro Techniques
Male
Mice
Models, Molecular
Molecular Conformation
Molecular Sequence Data
Morphinans
Muscle, Smooth drug effects
Mutation
Naltrexone chemical synthesis
Naltrexone metabolism
Naltrexone pharmacology
Narcotic Antagonists metabolism
Narcotic Antagonists pharmacology
Rats
Receptors, Opioid, kappa metabolism
Vas Deferens drug effects
Naltrexone analogs & derivatives
Narcotic Antagonists chemical synthesis
Receptors, Opioid, kappa antagonists & inhibitors
Receptors, Opioid, mu genetics
Receptors, Opioid, mu metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0022-2623
- Volume :
- 41
- Issue :
- 25
- Database :
- MEDLINE
- Journal :
- Journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 9836606
- Full Text :
- https://doi.org/10.1021/jm9805182