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p-Chloroamphetamine, a serotonin-releasing drug, elicited in rats a hyperglycemia mediated by the 5-HT1A and 5-HT2B/2C receptors.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 1998 Oct 23; Vol. 359 (2-3), pp. 185-90. - Publication Year :
- 1998
-
Abstract
- The effects of a serotonin (5-HT) releasing drug, p-chloroamphetamine, on plasma glucose levels were investigated in rats. p-Chloroamphetamine elicited a significant hyperglycemia. The hyperglycemic effects of p-chloroamphetamine were completely prevented by the 5-HT synthesis inhibitor, p-chlorophenylalanine. Prior adrenodemedullation abolished the hyperglycemia elicited by p-chloroamphetamine. p-Chloroamphetamine-induced hyperglycemia was prevented by methysergide, which blocks the 5-HT1 and 5-HT2 receptor, the 5-HT1A/1B/2C receptor antagonist, (-)-propranolol, the selective 5-HT1A receptor antagonist, 4-(2'-methoxyphenyl-1-[2'-n-2"pyridinyl)-p-iodobenzamido]-ethyl-pi perazine (p-MPPI), the 5-HT2A/2B/2C receptor antagonists, ritanserin and 4-isopropyl-7-methyl-9-(2-hydroxy-1-methyl-propoxycarbonyl)-4,6A,7 ,8,9,10,10A-octahydro-indolo[4,3-FG]quinolone maleate(LY 53857). However, the 5-HT3 and 5-HT4 receptor antagonist, tropisetron, the 5-HT4 receptor antagonist, 2-methoxy-4-amino-5-chloro-benzoic acid 2-(diethylamino) ethyl ester (SDZ 205-557), and the 5-HT2A receptor antagonist, ketanserin, did not affect the p-chloroamphetamine-induced hyperglycemia. These results suggest that p-chloroamphetamine-induced hyperglycemia is elicited by an enhanced 5-HT release and facilitated adrenaline release. Moreover, our results indicate that p-chloroamphetamine-induced hyperglycemia is mediated by 5-HT1A and 5-HT2B/2C receptors.
- Subjects :
- 4-Aminobenzoic Acid pharmacology
Adrenal Medulla physiology
Adrenalectomy
Aminopyridines pharmacology
Animals
Blood Glucose metabolism
Dose-Response Relationship, Drug
Ergolines pharmacology
Fenclonine pharmacology
Hyperglycemia physiopathology
Hyperglycemia prevention & control
Indoles pharmacology
Ketanserin pharmacology
Male
Methysergide pharmacology
Piperazines pharmacology
Propranolol pharmacology
Rats
Rats, Sprague-Dawley
Receptor, Serotonin, 5-HT2B
Receptor, Serotonin, 5-HT2C
Receptors, Serotonin, 5-HT1
Ritanserin pharmacology
Serotonin metabolism
Serotonin Antagonists pharmacology
Serotonin Antagonists therapeutic use
Tropisetron
para-Aminobenzoates
Blood Glucose drug effects
Hyperglycemia chemically induced
Receptors, Serotonin physiology
Serotonin Agents pharmacology
p-Chloroamphetamine pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2999
- Volume :
- 359
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 9832390
- Full Text :
- https://doi.org/10.1016/s0014-2999(98)00639-6