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[HLA-markers and diabetic retinopathy in the Senegalese population].
- Source :
-
Dakar medical [Dakar Med] 1998; Vol. 43 (1), pp. 29-33. - Publication Year :
- 1998
-
Abstract
- Patients with IDDM often develop severe forms of retinopathy, supposed to be associated to risk factors such as hypertension, poor glycemic control and nephropathy. A controversial intervention of a genetic marker was evoked so as some diabetic patients have retinopathy in the absence of known risk factors. HLA-DR and DQ markers were compared in two groups of patients with IDDM respectively constituted of patients with and without severe retinopathy. HLA typing was carried out by polymerase chain reaction (PCR) and restriction fragments of length polymorphism (RFLP). DR9 (p < 10(-4); O.R. = 8.36) and DQA1*0301 (p < 0.05; O.R = 2.92) alleles were positively associated to diabetic retinopathy, at the opposite of DR3 (p < 10(-3); O.R: 0.01) and DQA1* (p < 10(-9); O.R = 0.15). Furthermore, among the genotypes previously considered as risk markers of IDDM in senegalese people, only DR4: DQA1*0301:DQB1*0302/DR9: DQA1*0301: DQB1*0201 was often observed in retinopathy.
- Subjects :
- Adolescent
Adult
Alleles
Autoimmune Diseases epidemiology
Autoimmune Diseases immunology
Diabetes Mellitus, Type 1 complications
Diabetic Retinopathy epidemiology
Diabetic Retinopathy immunology
Female
Genetic Predisposition to Disease
Genotype
Haplotypes genetics
Humans
Male
Middle Aged
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Risk Factors
Senegal epidemiology
Autoimmune Diseases genetics
Diabetes Mellitus, Type 1 genetics
Diabetic Retinopathy genetics
HLA-DQ Antigens genetics
HLA-DR Antigens genetics
Subjects
Details
- Language :
- French
- ISSN :
- 0049-1101
- Volume :
- 43
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Dakar medical
- Publication Type :
- Academic Journal
- Accession number :
- 9827151