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Benazepril causes in hypertension a greater reduction in left ventricular mass than does nitrendipine: a randomized study using magnetic resonance imaging.
- Source :
-
Journal of cardiovascular pharmacology [J Cardiovasc Pharmacol] 1998 Nov; Vol. 32 (5), pp. 760-8. - Publication Year :
- 1998
-
Abstract
- To assess the comparative effects of benazepril and nitrendipine monotherapies on left ventricular mass index (LVMI) in hypertensive patients with echocardiographically determined left ventricular hypertrophy, patients with diastolic blood pressure (BP) > or = 100 mm Hg were randomized to benazepril, 10 mg, or nitrendipine, 20 mg, both given once or twice daily. After 4 weeks, only the responders (diastolic BP <90 mm Hg) entered a 5-month maintenance period. At baseline, and after 3 and 6 months, LVMI was blindly estimated by means of magnetic resonance imaging (MRI) and, for comparison, by means of echocardiography. Of the 50 randomized patients, three were excluded from the study as nonresponders after 4 weeks; moreover, two patients taking benazepril and one taking nitrendipine discontinued the treatment after 2 months for adverse effects. Both monotherapies reduced systolic and diastolic BP to a similar extent. After 3 months, MRI-estimated LVMI decreased by 21.5 g/m2 in the benazepril and 8.8 g/m2 in the nitrendipine group, with an adjusted mean difference between the two groups of 11.1 g/m2 (95% CI, 7.3-14.8 g/m2; p = 0.0001). After 6 months, it decreased by 23.6 g/m2 and 10.0 g/m2, respectively, with an adjusted mean difference of 11.3 g/m2 (95% CI, 7.5-15.5; p = 0.0001) in favor of benazepril. In conclusion, despite a similar antihypertensive effect, benazepril led to a greater reduction in MRI-measured LVMI than did nitrendipine (-16.2% vs. -7.2%) in hypertensive patients with left ventricular hypertrophy.
- Subjects :
- Adult
Aged
Blood Pressure drug effects
Echocardiography
Female
Heart Rate drug effects
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Prospective Studies
Ventricular Function, Left drug effects
Angiotensin-Converting Enzyme Inhibitors therapeutic use
Benzazepines therapeutic use
Calcium Channel Blockers therapeutic use
Hypertension drug therapy
Hypertrophy, Left Ventricular drug therapy
Nitrendipine therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0160-2446
- Volume :
- 32
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of cardiovascular pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 9821850
- Full Text :
- https://doi.org/10.1097/00005344-199811000-00012