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Antiserum to brain gangliosides produces recurrent epileptiform activity.
- Source :
-
Science (New York, N.Y.) [Science] 1976 Nov 12; Vol. 194 (4266), pp. 735-7. - Publication Year :
- 1976
-
Abstract
- A single injection of 10 microliters of antiserum to total brain ganglioside onto (and into) the sensorimotor cortex of the rat resulted in recurrent spiking in the cortical electroencephalogram, lasting from 7 to 17 days. Absorption of antibody with pure monosialoganglioside (GM1) completely abosished the effect. Spiking was reactivated after 4 weeks by intramuscular injection of pentylenetetrazole.
Details
- Language :
- English
- ISSN :
- 0036-8075
- Volume :
- 194
- Issue :
- 4266
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 982041
- Full Text :
- https://doi.org/10.1126/science.982041