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Morbillivirus downregulation of CD46.
- Source :
-
Journal of virology [J Virol] 1998 Dec; Vol. 72 (12), pp. 10292-7. - Publication Year :
- 1998
-
Abstract
- There is evidence that CD46 (membrane cofactor protein) is a cellular receptor for vaccine and laboratory-passaged strains of measles virus (MV). Following infection with these MV strains, CD46 is downregulated from the cell surface, and consequent complement-mediated lysis has been shown to occur upon infection of a human monocytic cell line. The MV hemagglutinin (H) protein alone is capable of inducing this downregulation. Some wild-type strains of MV fail to downregulate CD46, despite infection being prevented by anti-CD46 antibodies. In this study we show that CD46 is also downregulated to the same extent by wild-type, vaccine, and laboratory-passaged strains of rinderpest virus (RPV), although CD46 did not appear to be the receptor for RPV. Expression of the RPV H protein by a nonreplicating adenovirus vector was also found to cause this downregulation. A vaccine strain of peste des petits ruminants virus caused slight downregulation of CD46 in infected Vero cells, while wild-type and vaccine strains of canine distemper virus and a wild-type strain of dolphin morbillivirus failed to downregulate CD46. Downregulation of CD46 can, therefore, be a function independent of the use of this protein as a virus receptor.
- Subjects :
- Animals
Antibodies
Antigens, CD immunology
Cell Line
Chlorocebus aethiops
Distemper Virus, Canine immunology
Distemper Virus, Canine pathogenicity
Distemper Virus, Canine physiology
Dogs
Down-Regulation
Hemagglutinins, Viral physiology
Humans
Measles Vaccine pharmacology
Measles virus immunology
Measles virus pathogenicity
Measles virus physiology
Membrane Cofactor Protein
Membrane Glycoproteins immunology
Morbillivirus immunology
Morbillivirus physiology
Peste-des-petits-ruminants virus immunology
Peste-des-petits-ruminants virus pathogenicity
Peste-des-petits-ruminants virus physiology
Receptors, Virus immunology
Receptors, Virus physiology
Rinderpest virus immunology
Rinderpest virus pathogenicity
Rinderpest virus physiology
Vero Cells
Antigens, CD physiology
Membrane Glycoproteins physiology
Morbillivirus pathogenicity
Subjects
Details
- Language :
- English
- ISSN :
- 0022-538X
- Volume :
- 72
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of virology
- Publication Type :
- Academic Journal
- Accession number :
- 9811778
- Full Text :
- https://doi.org/10.1128/JVI.72.12.10292-10297.1998