Back to Search
Start Over
Cytogenetic and molecular study of 32 Down syndrome families: potential leukaemia predisposing role of the most proximal segment of chromosome 21q.
- Source :
-
British journal of haematology [Br J Haematol] 1998 Oct; Vol. 103 (1), pp. 213-6. - Publication Year :
- 1998
-
Abstract
- Down syndrome (DS) children have a 10-20-fold increased risk of developing ALL or AML compared to non-DS children. An increased disomic homozygosity of the polymorphic DNA markers in the pericentromeric region of chromosome 21q (21q11) has repeatedly been found in DS patients with ANLL-M7 and DS-specific transient abnormal myelopoiesis (TAM), compared to the majority of DS subjects without leukaemia. Analysis of cytogenetic heteromorphisms and 26 polymorphic DNA markers from chromosome 21q showed an increased number of pericentromeric crossovers between the non-disjoined chromosomes in DS-ANLL cases (3/11), compared to DS-ALL (0/9) and DS-nonleukaemic cases (0/12). These findings are compatible with the model of disomic homozygosity of the predisposing allele of a putative pericentromeric gene, as an explanation for the high prevalence of ANLL in DS.
- Subjects :
- Down Syndrome complications
Genetic Predisposition to Disease
Homozygote
Humans
Leukemia, Myeloid, Acute complications
Pedigree
Precursor Cell Lymphoblastic Leukemia-Lymphoma complications
Risk Factors
Chromosomes, Human, Pair 21 genetics
Down Syndrome genetics
Leukemia, Myeloid, Acute genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0007-1048
- Volume :
- 103
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 9792310
- Full Text :
- https://doi.org/10.1046/j.1365-2141.1998.00924.x