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Dexamethasone on inducible nitric oxide synthase and nitrite/nitrate production in myocardial infarction.
- Source :
-
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) [Proc Soc Exp Biol Med] 1998 Nov; Vol. 219 (2), pp. 138-43. - Publication Year :
- 1998
-
Abstract
- The effect of dexamethasone (DEX) on the activation of the inducible form of nitric oxide synthase (iNOS) and its relation to the formation of oxidation products of nitric oxide (NO2-+ NO3-, NOx) in infarcted heart muscle of rabbits was investigated. Myocardial infarction was produced by ligation of the first anterior branch of the left circumflex coronary artery. NOx was determined by chemiluminescence and iNOS by conversion of L-[14C]-arginine to L-[14C]-citrulline. The rise in myocardial iNOS production, which followed onset of myocardial ischemia, was suppressed by DEX. In addition, following coronary artery ligation, coronary arterial venous differences of NOx increased markedly; this effect was also partially abolished by DEX. Cardiac origin of NOx was confirmed by the linear relationship between coronary A-V NOx difference and myocardial formation of iNOS. This relationship was preserved after administration of DEX. Therefore glucocorticoids interfere with the myocardial NO production and thus diminish the concentration of its oxidative products in plasma.
- Subjects :
- Animals
Dexamethasone therapeutic use
Enzyme Induction drug effects
Glucocorticoids therapeutic use
Heart drug effects
Male
Myocardial Infarction drug therapy
Nitric Oxide Donors metabolism
Rabbits
Dexamethasone pharmacology
Glucocorticoids pharmacology
Myocardial Infarction metabolism
Nitrates metabolism
Nitric Oxide metabolism
Nitric Oxide Synthase drug effects
Nitric Oxide Synthase metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0037-9727
- Volume :
- 219
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 9790171
- Full Text :
- https://doi.org/10.3181/00379727-219-44326