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Scanning mutagenesis of transmembrane domain 3 of the M1 muscarinic acetylcholine receptor.
- Source :
-
Journal of physiology, Paris [J Physiol Paris] 1998 Jun-Aug; Vol. 92 (3-4), pp. 269-74. - Publication Year :
- 1998
-
Abstract
- Scanning mutagenesis of transmembrane domain 3 of the M1 muscarinic acetylcholine receptor has revealed a highly-differentiated alpha-helical structure. Lipid-facing residues are distinguished from a patch of residues which selectively stabilise the ground state of the receptor, and from a band of amino acids extending the full length of the helix, which contribute to the active agonist-receptor-G protein complex. The most important residues are strongly conserved in the GPCR superfamily.
Details
- Language :
- English
- ISSN :
- 0928-4257
- Volume :
- 92
- Issue :
- 3-4
- Database :
- MEDLINE
- Journal :
- Journal of physiology, Paris
- Publication Type :
- Academic Journal
- Accession number :
- 9789821
- Full Text :
- https://doi.org/10.1016/s0928-4257(98)80031-4