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Is the single use of intraoperative 5-fluorouracil in filtering surgery for high-risk cases enough?
- Source :
-
Eye (London, England) [Eye (Lond)] 1998; Vol. 12 ( Pt 3a), pp. 374-8. - Publication Year :
- 1998
-
Abstract
- Purpose: To study the efficacy of the adjunctive use of a single intraoperative application of 5-fluorouracil (5FU) in eyes with poor prognoses for a successful outcome with a trabeculectomy.<br />Method: Twenty-four patients (25 eyes) with a mean age of 63.7 +/- 14.7 years (range 27-86 years) and a history of one or more risk factors (age < 50 years, more than 3 years on topical medication, a previous failed filter, previous cataract surgery, uveitis, neovascular glaucoma) underwent trabeculectomy with the intraoperative application of 5FU on a sponge (25 mg/ml) for 5 min. The average follow-up was 10.1 +/- 5.5 months.<br />Results: The mean pre-operative intraocular pressure (IOP) was 24.7 +/- 6.2 mmHg and the mean post-operative IOP was 13.9 +/- 3.5 mmHg. Success, defined as an IOP within desired target levels for a particular eye, in the presence of a functioning filter, without supplementary medical therapy, was achieved in 56.5% of cases.<br />Conclusions: Our results of successful filters in this group of patients with moderate- to high-risk characteristics approach similar figures quoted for trabeculectomies without the adjunctive use of intraoperative 5FU in eyes with poor prognoses with a similar length of follow-up. Though the numbers are small there is a trend that indicates that the intraoperative application of a single dose of 5FU alone may not be sufficient in eyes with moderate- to high-risk characteristics of failure of a trabeculectomy.
- Subjects :
- Adult
Aged
Aged, 80 and over
Drug Administration Schedule
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prognosis
Risk Factors
Treatment Outcome
Antimetabolites administration & dosage
Fluorouracil administration & dosage
Intraoperative Care
Postoperative Complications prevention & control
Trabeculectomy
Subjects
Details
- Language :
- English
- ISSN :
- 0950-222X
- Volume :
- 12 ( Pt 3a)
- Database :
- MEDLINE
- Journal :
- Eye (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 9775234
- Full Text :
- https://doi.org/10.1038/eye.1998.89