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[Paraneoplastic intestinal pseudo-obstruction revealing small cell lung carcinoma: "the anti-Hu syndrome"].
- Source :
-
Gastroenterologie clinique et biologique [Gastroenterol Clin Biol] 1998 Mar; Vol. 22 (3), pp. 346-8. - Publication Year :
- 1998
-
Abstract
- A 67-year-old woman was admitted for intestinal pseudoobstruction associated with peripheral sensitive neuropathy. Jejunal biopsies performed during laparotomy, showed axonal degeneration and lympho-plasmocytic infiltration in myenteric plexus. High titer of seric anti-Hu antibodies suggested a paraneoplastic syndrome. Thoracic CT scan showed mediastinal lymph nodes. Their histological examination confirmed the diagnosis of metastatic small-cell lung carcinoma. Her condition gradually deteriorated despite supportive parenteral nutrition, chemotherapy, steroids and intravenous immunoglobulins. She died 12 months after the onset of symptoms.
- Subjects :
- Aged
Antibodies analysis
Biopsy
Carcinoma, Small Cell immunology
Carcinoma, Small Cell pathology
ELAV Proteins
Female
Humans
Intestinal Pseudo-Obstruction immunology
Jejunum innervation
Jejunum pathology
Laparotomy
Lung Neoplasms immunology
Lung Neoplasms pathology
Paraneoplastic Syndromes immunology
Radiography, Thoracic
Retrograde Degeneration
Tomography, X-Ray Computed
Carcinoma, Small Cell complications
Intestinal Pseudo-Obstruction complications
Lung Neoplasms complications
Nerve Tissue Proteins
Paraneoplastic Syndromes complications
RNA-Binding Proteins immunology
Subjects
Details
- Language :
- French
- ISSN :
- 0399-8320
- Volume :
- 22
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Gastroenterologie clinique et biologique
- Publication Type :
- Academic Journal
- Accession number :
- 9762221