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Induction of endothelial cell adhesion molecules by serum and immunoglobulins G from a patient with vasculitis and monoclonal gammapathy: potential relevance to vasculitis.
- Source :
-
Thrombosis and haemostasis [Thromb Haemost] 1998 Sep; Vol. 80 (3), pp. 477-80. - Publication Year :
- 1998
-
Abstract
- Interactions between endothelial cell adhesion molecules and their beta2 integrin adhesive receptors on leukocytes are thought to play a role in the pathogenesis of inflammatory diseases and probably vasculitis. We describe a case in whom leukocytoclastic vasculitis was associated to a monoclonal immunoglobulin G2 kappa (IgG2K). During the vasculitic crisis, the patient's serum and the isolated IgG from this serum induced the expression of E-selectin, VCAM-1 and ICAM-1 at the HUVEC surface, but not tissue factor activity, whereas normal, control serum and patient serum at remission were without any effect. A close relationship between the vasculitis and the serum level of the monoclonal IgG was observed. We suggest that the monoclonal IgG might induce the vasculitis by increasing the expression of E-selectin, VCAM-1 and ICAM-1 which facilitate the interaction of leukocytes with vascular endothelium.
- Subjects :
- Aged
Endothelium, Vascular metabolism
Humans
Immunoglobulin G blood
Immunoglobulin G immunology
Male
Paraproteinemias blood
Vasculitis blood
E-Selectin biosynthesis
Endothelium, Vascular drug effects
Endothelium, Vascular immunology
Immunoglobulin G pharmacology
Intercellular Adhesion Molecule-1 biosynthesis
Paraproteinemias immunology
Vascular Cell Adhesion Molecule-1 biosynthesis
Vasculitis immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0340-6245
- Volume :
- 80
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Thrombosis and haemostasis
- Publication Type :
- Academic Journal
- Accession number :
- 9759630