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GABA (gamma-amino-butyric acid) neurotransmission: identification and fine mapping of the human GABAB receptor gene.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1998 Sep 18; Vol. 250 (2), pp. 240-5. - Publication Year :
- 1998
-
Abstract
- GABA (gamma-amino-butyric acid) receptors are a family of proteins involved in the GABAergic neurotransmission of the mammalian central nervous system (CNS). They have physiological importance and clinical relevance in several diseases. We report the identification, cloning, and fine mapping of the human cDNA for GABAB receptor. A 4.2-Kb cDNA containing an open reading frame for a predicted protein of 960 aa was isolated from a fetal brain cDNA library. It had a strong identity (91.5%) with the rat GABAB receptor (rGB1A) nucleotide sequence, that corresponded to 98.6% identity at the amino acid level. Expression of the GABAB at the transcription level was detected by Northern analysis in all brain areas examined. The GABAB receptor has been mapped to human chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have been suggested to map in this region.
- Subjects :
- Amino Acid Sequence
Animals
Base Sequence
DNA, Complementary analysis
Humans
Molecular Sequence Data
Rats
Receptors, GABA-B metabolism
Sequence Alignment
Sequence Analysis, DNA
Signal Transduction
Chromosome Mapping
DNA, Complementary genetics
Receptors, GABA-B genetics
gamma-Aminobutyric Acid metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0006-291X
- Volume :
- 250
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 9753614
- Full Text :
- https://doi.org/10.1006/bbrc.1998.9296