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Effect of rebamipide on Helicobacter pylori infection in patients with peptic ulcer.
- Source :
-
Digestive diseases and sciences [Dig Dis Sci] 1998 Sep; Vol. 43 (9 Suppl), pp. 203S-206S. - Publication Year :
- 1998
-
Abstract
- This study was designed to assess whether the gastroprotective drug, rebamipide, aids in eradication of H. pylori. One hundred twenty patients, endoscopically diagnosed with gastric or duodenal ulcers and H. pylori infection, were randomly allocated to two treatment groups. Sixty patients received 40 mg of omeprazole twice a day, 1500 mg of amoxicillin three times a day, and 300 mg of rebamipide three times a day (group OAR); the other 60 patients received the same dosage of omeprazole and amoxicillin but no rebamipide for two weeks (group OA). All patients subsequently received an H2-receptor antagonist for six weeks. At the end of the treatment, endoscopy was performed to assess the status of the ulcers as well as the extent of H. pylori infection. In the intent-to-treat (73.3 vs 51.7%, P = 0.014) and per-protocol analyses (75.9 vs 55.3%, P = 0.021) the cure rates for H. pylori infection in group OAR were found to be significantly higher than those in group OA. Our findings suggest that rebamipide aids in curing H. pylori infection. This drug does not induce formation of resistant colonies and has few side effects.
- Subjects :
- Adult
Aged
Alanine therapeutic use
Drug Therapy, Combination
Duodenal Ulcer microbiology
Female
Helicobacter Infections microbiology
Humans
Male
Middle Aged
Peptic Ulcer microbiology
Stomach Ulcer microbiology
Treatment Outcome
Alanine analogs & derivatives
Amoxicillin therapeutic use
Anti-Ulcer Agents therapeutic use
Duodenal Ulcer drug therapy
Helicobacter Infections drug therapy
Helicobacter pylori drug effects
Omeprazole therapeutic use
Penicillins therapeutic use
Peptic Ulcer drug therapy
Quinolones therapeutic use
Stomach Ulcer drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0163-2116
- Volume :
- 43
- Issue :
- 9 Suppl
- Database :
- MEDLINE
- Journal :
- Digestive diseases and sciences
- Publication Type :
- Academic Journal
- Accession number :
- 9753251