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Determination of the inhibitory effect on Toxoplasma growth in the serum of AIDS patients during acute therapy for toxoplasmic encephalitis.
- Source :
-
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association [J Acquir Immune Defic Syndr Hum Retrovirol] 1998 Sep 01; Vol. 19 (1), pp. 50-4. - Publication Year :
- 1998
-
Abstract
- In 26 AIDS patients treated for toxoplasmic encephalitis, the inhibitory effect on Toxoxplasma growth of sequential sera taken before and after initiation of therapy was determined using a culture-based immunoassay and compared with pyrimethamine blood levels. A marked inhibition of Toxoplasma growth was observed 1 day after initiation of therapy with pyrimethamine plus sulfadiazine and was maintained between 67% and 93% throughout the 15-day follow-up period. The degree of inhibition was not correlated to pyrimethamine blood levels and seemed highly potentiated when sulfadiazine rather than macrolides was given in combination with pyrimethamine.
- Subjects :
- Acquired Immunodeficiency Syndrome blood
Adult
Animals
Anti-Bacterial Agents pharmacology
Anti-Bacterial Agents therapeutic use
Anti-Infective Agents blood
Anti-Infective Agents pharmacology
Drug Therapy, Combination
Encephalitis parasitology
Female
Follow-Up Studies
Humans
Macrolides
Male
Pyrimethamine blood
Pyrimethamine pharmacology
Sulfadiazine pharmacology
Toxoplasma growth & development
Toxoplasmosis, Cerebral parasitology
Acquired Immunodeficiency Syndrome complications
Anti-Infective Agents therapeutic use
Encephalitis drug therapy
Pyrimethamine therapeutic use
Sulfadiazine therapeutic use
Toxoplasma drug effects
Toxoplasmosis, Cerebral drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1077-9450
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association
- Publication Type :
- Academic Journal
- Accession number :
- 9732069
- Full Text :
- https://doi.org/10.1097/00042560-199809010-00008