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Peptide-specific T cell response to Mycobacterium tuberculosis: clinical spectrum, compartmentalization, and effect of chemotherapy.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 1998 Sep; Vol. 178 (3), pp. 760-8. - Publication Year :
- 1998
-
Abstract
- The T cell repertoire of 59 patients with untreated tuberculosis was compared with that of 46 bacille Calmette-Guérin-vaccinated controls by assaying the proliferative responses to six permissively recognized peptides from the 16-, 19-, and 38-kDa molecules of Mycobacterium tuberculosis. A trend from higher to lower reactivity following this order: vaccinated controls > lymph node disease > localized extrapulmonary > pulmonary > pleural was seen for 4 of the peptides (P < .03). The decreased response of blood lymphocytes from patients with pleural tuberculosis was partially accounted for by sequestration of peptide-responsive cells within the pleural fluid. Chemotherapy "reversed" the depressed proliferative responses of patients with pulmonary and pleural tuberculosis depending on the peptide origin, being greatest for peptides of 16 kDa, transient for those of 19 kDa, and least for those of 38 kDa. These data demonstrate antigen specificity in the decreased responsiveness of patients with tuberculosis.
- Subjects :
- Adolescent
Adult
BCG Vaccine immunology
Bacterial Proteins chemical synthesis
Cell Division
Cells, Cultured
Epitopes, T-Lymphocyte immunology
Ethambutol therapeutic use
Female
Humans
Interferon-gamma biosynthesis
Interleukin-10 biosynthesis
Isoniazid therapeutic use
Leukocytes, Mononuclear cytology
Male
Middle Aged
Peptides chemical synthesis
Peptides immunology
Pleural Effusion cytology
Pyrazinamide therapeutic use
Rifampin therapeutic use
Tuberculin metabolism
Tuberculin pharmacology
Tuberculosis drug therapy
Tuberculosis prevention & control
Antigens, Bacterial immunology
Antitubercular Agents therapeutic use
Bacterial Proteins immunology
Lipoproteins
Mycobacterium tuberculosis immunology
T-Lymphocytes immunology
Tuberculosis immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 178
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 9728545
- Full Text :
- https://doi.org/10.1086/515336