Back to Search
Start Over
Insulin-like growth factor-I (IGF-I) stimulates regrowth of the damaged intestine in rats, when administered following, but not concurrent with, methotrexate.
- Source :
-
Growth factors (Chur, Switzerland) [Growth Factors] 1998; Vol. 15 (4), pp. 279-92. - Publication Year :
- 1998
-
Abstract
- Background: We tested the ability of insulin-like growth factor-I (IGF-I) to reduce damage to the intestinal mucosa (mucositis) in rats injected with methotrexate. IGF-I was infused concurrent with methotrexate administration and compared to IGF-I administered following the withdrawal of methotrexate.<br />Methods: Rats were injected with methotrexate at the start of days 1, 2 and 3. IGF-I was infused for 5 days, commencing at the start of day 1 [concurrent administration] or at the start of day 4 [post-methotrexate administration].<br />Results: IGF-I administered coincident with methotrexate failed to restore mucosal integrity to the damaged small intestine. IGF-I administered post methotrexate stimulated regrowth of the damaged intestine, particularly the ileum, with 22%, 32% and 29% increases in small intestinal weight, ileal villus height and ileal crypt depth respectively.<br />Conclusions: Following intestinal damage of methotrexate, IGF-I primarily induced growth of the distal small intestine. The ineffectiveness of concurrently administered IGF-I may have represented an IGF-I induced recruitment of proliferating epithelial cells to the anti-proliferative effects of methotrexate.
- Subjects :
- Animals
DNA analysis
Insulin-Like Growth Factor Binding Proteins blood
Intestinal Mucosa drug effects
Male
Organ Size
Proteins analysis
Rats
Rats, Sprague-Dawley
Sucrase metabolism
Antimetabolites, Antineoplastic administration & dosage
Insulin-Like Growth Factor I administration & dosage
Intestinal Mucosa physiology
Methotrexate administration & dosage
Regeneration physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0897-7194
- Volume :
- 15
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Growth factors (Chur, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 9714912
- Full Text :
- https://doi.org/10.3109/08977199809017483