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Insulin-like growth factor-I (IGF-I) stimulates regrowth of the damaged intestine in rats, when administered following, but not concurrent with, methotrexate.

Authors :
Howarth GS
Cool JC
Bourne AJ
Ballard FJ
Read LC
Source :
Growth factors (Chur, Switzerland) [Growth Factors] 1998; Vol. 15 (4), pp. 279-92.
Publication Year :
1998

Abstract

Background: We tested the ability of insulin-like growth factor-I (IGF-I) to reduce damage to the intestinal mucosa (mucositis) in rats injected with methotrexate. IGF-I was infused concurrent with methotrexate administration and compared to IGF-I administered following the withdrawal of methotrexate.<br />Methods: Rats were injected with methotrexate at the start of days 1, 2 and 3. IGF-I was infused for 5 days, commencing at the start of day 1 [concurrent administration] or at the start of day 4 [post-methotrexate administration].<br />Results: IGF-I administered coincident with methotrexate failed to restore mucosal integrity to the damaged small intestine. IGF-I administered post methotrexate stimulated regrowth of the damaged intestine, particularly the ileum, with 22%, 32% and 29% increases in small intestinal weight, ileal villus height and ileal crypt depth respectively.<br />Conclusions: Following intestinal damage of methotrexate, IGF-I primarily induced growth of the distal small intestine. The ineffectiveness of concurrently administered IGF-I may have represented an IGF-I induced recruitment of proliferating epithelial cells to the anti-proliferative effects of methotrexate.

Details

Language :
English
ISSN :
0897-7194
Volume :
15
Issue :
4
Database :
MEDLINE
Journal :
Growth factors (Chur, Switzerland)
Publication Type :
Academic Journal
Accession number :
9714912
Full Text :
https://doi.org/10.3109/08977199809017483