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Evolution to malignancy in a recurrent meningioma: morphological and cytogenetic findings.

Evolution to malignancy in a recurrent meningioma: morphological and cytogenetic findings.

Authors :
Cerdá-Nicolás M
López-Ginés C
Barcia-Salorio J
Llombart-Bosch A
Source :
Clinical neuropathology [Clin Neuropathol] 1998 Jul-Aug; Vol. 17 (4), pp. 210-5.
Publication Year :
1998

Abstract

The original tumor and 4 relapses of a recurrent meningioma were studied. We analyzed and compared these recurrences by histopathology, PCNA labelling index (PCNA-LI), nuclear count, and cytogenetical findings. The most important changes in the evolution to aggressivity were: recurrences at progressively shorter intervals, increases in the PCNA-LI, and micronecrosis; histological changes such as sheeting and increase of the extracellular matrix and a gradual transformation to a clonally complex karyotype.

Details

Language :
English
ISSN :
0722-5091
Volume :
17
Issue :
4
Database :
MEDLINE
Journal :
Clinical neuropathology
Publication Type :
Academic Journal
Accession number :
9707336