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Evolution to malignancy in a recurrent meningioma: morphological and cytogenetic findings.
Evolution to malignancy in a recurrent meningioma: morphological and cytogenetic findings.
- Source :
-
Clinical neuropathology [Clin Neuropathol] 1998 Jul-Aug; Vol. 17 (4), pp. 210-5. - Publication Year :
- 1998
-
Abstract
- The original tumor and 4 relapses of a recurrent meningioma were studied. We analyzed and compared these recurrences by histopathology, PCNA labelling index (PCNA-LI), nuclear count, and cytogenetical findings. The most important changes in the evolution to aggressivity were: recurrences at progressively shorter intervals, increases in the PCNA-LI, and micronecrosis; histological changes such as sheeting and increase of the extracellular matrix and a gradual transformation to a clonally complex karyotype.
- Subjects :
- Cell Transformation, Neoplastic genetics
Chromosome Breakage
Extracellular Matrix pathology
Humans
Karyotyping
Male
Meningeal Neoplasms genetics
Meninges pathology
Meningioma genetics
Microscopy, Electron
Middle Aged
Necrosis
Neoplasm Recurrence, Local genetics
Proliferating Cell Nuclear Antigen genetics
Cell Transformation, Neoplastic pathology
Meningeal Neoplasms pathology
Meningioma pathology
Neoplasm Recurrence, Local pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0722-5091
- Volume :
- 17
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Clinical neuropathology
- Publication Type :
- Academic Journal
- Accession number :
- 9707336