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Association of Helicobacter pylori infection with gastric adenocarcinoma.
- Source :
-
Japanese journal of cancer research : Gann [Jpn J Cancer Res] 1998 Jun; Vol. 89 (6), pp. 597-603. - Publication Year :
- 1998
-
Abstract
- Gastric adenocarcinoma is the most prevalent cancer in South Korea, and Helicobacter pylori (H. pylori) infection is also common. This study was performed to examine the association between H. pylori infection and gastric cancer, taking into account various other factors. To investigate the association between gastric adenocarcinoma and H. pylori infection, determined by urease-positive reaction in the CLO test, a total of 175 paired specimens (175 tumor and 175 tissues adjacent to tumor) of stomach cancer patients and a total of 113 control specimens were obtained. The positive H. pylori infection rates were 78.9% (138/175) among the patients in specimens of tumor or tissues adjacent to the tumor and 41.6% (47/113) among controls in the CLO test. A positive correlation between H. pylori infection and gastric cancer was observed (age-adjusted odds ratio, 7.0; MH chi2=34.5 with P<0.0005). These data suggest that stomach cancer patients in Korea have high infection rates of H. pylori regardless of site specificity, and this infection might be causally associated with stomach cancer.
- Subjects :
- Adenocarcinoma microbiology
Adult
Aged
Clinical Enzyme Tests
Comorbidity
Helicobacter Infections diagnosis
Helicobacter pylori enzymology
Humans
Korea epidemiology
Male
Middle Aged
Stomach enzymology
Stomach microbiology
Stomach Neoplasms microbiology
Urease analysis
Adenocarcinoma epidemiology
Helicobacter Infections epidemiology
Helicobacter pylori isolation & purification
Stomach Diseases microbiology
Stomach Neoplasms epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 0910-5050
- Volume :
- 89
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Japanese journal of cancer research : Gann
- Publication Type :
- Academic Journal
- Accession number :
- 9703356
- Full Text :
- https://doi.org/10.1111/j.1349-7006.1998.tb03260.x