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Cimetidine reduces impairment of cellular immunity after cardiac operations with cardiopulmonary bypass.
- Source :
-
The Journal of thoracic and cardiovascular surgery [J Thorac Cardiovasc Surg] 1998 Aug; Vol. 116 (2), pp. 312-8. - Publication Year :
- 1998
-
Abstract
- Objective: Depressive effects of cardiopulmonary bypass on cell-mediated immune responses may lead to postoperative infectious complications. We previously reported that cimetidine reduced postbypass depression of the cytotoxic activity of natural killer cells. This study evaluated cimetidine as an agent to preserve cellular immunity after cardiac operations.<br />Methods: In a prospective randomized study, 20 patients were divided into two groups of equal size. Cimetidine-group patients received 400 mg of cimetidine intravenously before bypass and a 33 mg/hr intravenous infusion of cimetidine after the operation, continuing until the fifth postoperative day. Control-group patients received conventional perioperative therapy. Lymphocyte subsets, natural killer cell activity, percentage of CD56+CD16+ (percentage of natural killer cells), and percentage of CD11b+CD8+ (percentage of suppressor T lymphocytes) were measured perioperatively.<br />Results: Although temporary postoperative reductions in percentages of CD3+, CD4+, and CD56+CD16+ cells were observed in both groups, CD8+ percentages on postoperative day 1 and CD11b+CD8+ percentages on postoperative days 1 and 3 in the cimetidine group were significantly lower compared with those in the control group (p = 0.01,p = 0.004, andp = 0.02, respectively). Temporary postoperative reduction of natural killer cell activity was also observed in both groups, but the natural killer cell activity on postoperative day 1 in the cimetidine group (17.1%) was significantly higher (p = 0.02) than that in the control group (8.20%).<br />Conclusions: Cimetidine counteracts depressive effects of cardiopulmonary bypass on cell-mediated immunity and may possibly reduce postoperative susceptibility to infection.
- Subjects :
- Antigens, CD immunology
CD4-CD8 Ratio
Cimetidine administration & dosage
Female
Follow-Up Studies
Histamine H2 Antagonists administration & dosage
Humans
Immunity, Cellular immunology
Infusions, Intravenous
Killer Cells, Natural drug effects
Killer Cells, Natural immunology
Lymphocyte Activation drug effects
Lymphocyte Subsets immunology
Male
Middle Aged
Prospective Studies
Surgical Wound Infection immunology
Surgical Wound Infection prevention & control
Cardiac Surgical Procedures adverse effects
Cardiopulmonary Bypass adverse effects
Cimetidine therapeutic use
Histamine H2 Antagonists therapeutic use
Immunity, Cellular drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0022-5223
- Volume :
- 116
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of thoracic and cardiovascular surgery
- Publication Type :
- Academic Journal
- Accession number :
- 9699585
- Full Text :
- https://doi.org/10.1016/s0022-5223(98)70132-1