[Genetic polymorphism of inter-alpha-trypsin inhibitor in six Chinese populations].

Objective: To understand the distribution of allele frequencies of inter-alpha-trypsin inhibitor(ITI) in Chinese populations.
Methods: The polymorphism of this protein in six Chinese populations was investigated using isoelectric focusing followed by immunoblotting technique.
Results: Three common alleles, ITI*1, ITI*2, and ITI*3 were observed in four populations, namely Han living in Jilin, Mongol in Hailaer, Tibetan in Lasa, and Bai in Dali respectively. In other two populations, Zhuang in Guangxi and Han in Guangdong, only ITI*1 and ITI*2 were observed. For these populations, the frequency of ITI*1 ranges from 0.5500 to 0.7525; that of ITI*2 from 0.2475 to 0.4322; and that of ITI*3 from 0.0034 to 0.0729.
Conclusion: This study reveals that there is no parallel relationship between variation of allele frequencies and geographic differences.