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Down-modulation of a novel Bax-associated protein during apoptosis in normal mature B lymphocytes.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 1998 Aug 01; Vol. 161 (3), pp. 1176-82. - Publication Year :
- 1998
-
Abstract
- We have recently characterized a novel 16-kDa Bax-associated protein. In this study, we investigate the regulation of this protein's expression during in vitro induction of apoptosis in mature splenic B cells. A panel of biochemically distinct apoptotic stimuli induced the dramatic down-modulation of the 16-kDa protein in B cells; this down-modulation was rapid, and did not require DNA fragmentation. Reciprocally, stimuli that induced protection from apoptosis prevented down-modulation of the 16-kDa protein. These regulatory effects were specific, since Bcl-2 and Bax protein levels were not similarly modulated. Stimuli that reduce expression of the 16-kDa protein may therefore act indirectly to increase the proapoptotic activity of Bax, perhaps by altering Bax binding to other cellular proteins.
- Subjects :
- Animals
Apoptosis drug effects
B-Lymphocytes cytology
B-Lymphocytes immunology
Carrier Proteins immunology
Carrier Proteins physiology
Cell Differentiation immunology
Female
Interleukin-4 pharmacology
Mice
Mice, Inbred C57BL
Proto-Oncogene Proteins c-bcl-2 physiology
Time Factors
bcl-2-Associated X Protein
Apoptosis immunology
B-Lymphocytes metabolism
Carrier Proteins biosynthesis
Carrier Proteins chemistry
Down-Regulation immunology
Proto-Oncogene Proteins metabolism
Proto-Oncogene Proteins c-bcl-2 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1767
- Volume :
- 161
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 9686577