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Localization of neuroendocrine tumours with [111In] DTPA-octreotide scintigraphy (Octreoscan): a comparative study with CT and MR imaging.
- Source :
-
QJM : monthly journal of the Association of Physicians [QJM] 1998 Apr; Vol. 91 (4), pp. 295-301. - Publication Year :
- 1998
-
Abstract
- A wide variety of neuroendocrine tumours express somatostatin receptors, and can be visualized by radiolabelled somatostatin analogue scintigraphy. To investigate the value of [111In]-octreotide scintigraphy (Octreoscan), 48 patients (37 with proven carcinoid, pancreatic endocrine and medullary carcinoma of thyroid tumours, 11 with neuroendocrine syndromes multiple endocrine neoplasia (MEN-I) and Zollinger-Ellison syndrome (ZES) were examined with 111In-DTPA-D-Phe1-octreotide. Scintigrams were obtained at 24 and 48 h, and the results were compared with CT and magnetic resonance imaging (MRI). Thirty-five of 48 patients had positive [111In]-octreotide scintigraphy (23/25 (92%) carcinoids, 8/9 (89%) PETs, 4/11 (36%) MEN-I & ZES). Of the 42 lesions located by conventional imaging techniques, 37 (88%) were also identified by Octreoscan. Unexpected lesions (40 sites), not detected by CT or MR imaging were found in 24/48 (50%) patients. [111In]-octreotide scintigraphy has a higher sensitivity for tumour detection, and is superior to MR imaging and CT scanning in the identification of previously unsuspected extraliver and lymph node metastases. It may also be helpful for the localization of clinically suspected tumours in patients with MEN-I and ZES.
- Subjects :
- Adolescent
Adult
Aged
Carcinoid Tumor diagnosis
Carcinoid Tumor diagnostic imaging
Carcinoma, Medullary diagnosis
Carcinoma, Medullary diagnostic imaging
Child
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neuroendocrine Tumors diagnosis
Pancreatic Neoplasms diagnosis
Pancreatic Neoplasms diagnostic imaging
Radionuclide Imaging
Sensitivity and Specificity
Thyroid Neoplasms diagnosis
Thyroid Neoplasms diagnostic imaging
Tomography, X-Ray Computed
Indium Radioisotopes
Neuroendocrine Tumors diagnostic imaging
Octreotide analogs & derivatives
Pentetic Acid analogs & derivatives
Radiopharmaceuticals
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2725
- Volume :
- 91
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- QJM : monthly journal of the Association of Physicians
- Publication Type :
- Academic Journal
- Accession number :
- 9666953
- Full Text :
- https://doi.org/10.1093/qjmed/91.4.295