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[Blood levels of soluble ICAM-1 in patients with multiple sclerosis].
- Source :
-
Revista de neurologia [Rev Neurol] 1998 Jun; Vol. 26 (154), pp. 926-9. - Publication Year :
- 1998
-
Abstract
- Introduction: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. The Intercellular Adhesion Molecule plays a fundamental part in the migration of T cells to the inflammed tissues. It is known that there is an increase in the expression of endothelial cells and other cells found in lesions of the central nervous system of MS patients. ICAM-I may be detected in its soluble form in serum and it is of interest to understand its behaviour in this liquid since it is easily accessible.<br />Material and Methods: We studied the concentration of soluble ICAM-I in the serum of patients with MS: one group which had clinical attacks were studied whilst in remission; another had the chronic progressive clinical form and a third group had optic neuritis as the probable initial sign of the disorder. Within the different clinical forms, some patients received treatment with beta-interferon or azathioprine and others did not.<br />Results and Conclusions: We found a significant increase in the levels of soluble ICAM-I in patients with inactive, untreated MS as compared with normal persons, with no difference found between the different clinical types.
- Subjects :
- Autoimmune Diseases complications
Autoimmune Diseases drug therapy
Autoimmune Diseases therapy
Azathioprine therapeutic use
Humans
Immunologic Factors therapeutic use
Immunosuppressive Agents therapeutic use
Interferon-beta therapeutic use
Multiple Sclerosis complications
Multiple Sclerosis drug therapy
Multiple Sclerosis therapy
Nervous System Diseases blood
Optic Neuritis blood
Optic Neuritis etiology
Solubility
Autoimmune Diseases blood
Intercellular Adhesion Molecule-1 blood
Multiple Sclerosis blood
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 0210-0010
- Volume :
- 26
- Issue :
- 154
- Database :
- MEDLINE
- Journal :
- Revista de neurologia
- Publication Type :
- Academic Journal
- Accession number :
- 9658462