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Spontaneous skin ulceration and defective T cell function in CD18 null mice.
- Source :
-
The Journal of experimental medicine [J Exp Med] 1998 Jul 06; Vol. 188 (1), pp. 119-31. - Publication Year :
- 1998
-
Abstract
- A null mutation was prepared in the mouse for CD18, the beta2 subunit of leukocyte integrins. Homozygous CD18 null mice develop chronic dermatitis with extensive facial and submandibular erosions. The phenotype includes elevated neutrophil counts, increased immunoglobulin levels, lymphadenopathy, splenomegaly, and abundant plasma cells in skin, lymph nodes, gut, and kidney. Very few neutrophils were found in spontaneously occurring skin lesions or with an induced toxic dermatitis. Intravital microscopy in CD18 null mice revealed a lack of firm neutrophil attachment to venules in the cremaster muscle in response to N-formyl- methionyl-leucyl-phenylalanine. A severe defect in T cell proliferation was found in the CD18 null mice when T cell receptors were stimulated either by staphylococcal enterotoxin A or by major histocompatibility complex alloantigens demonstrating a greater role of CD11/CD18 integrins in T cell responses than previously documented. The null mice are useful for delineating the functions of CD18 in vivo.
- Subjects :
- Animals
CD18 Antigens physiology
Cell Adhesion genetics
Cell Adhesion physiology
Cell Division genetics
Disease Models, Animal
Enterotoxins pharmacology
Histocytochemistry
Humans
Mice
Mice, Knockout
Neutrophils metabolism
Phenotype
Receptors, Antigen, T-Cell metabolism
Respiratory Burst genetics
Streptococcus pneumoniae pathogenicity
Zymosan pharmacology
CD18 Antigens genetics
Leukocyte-Adhesion Deficiency Syndrome etiology
Skin Ulcer genetics
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1007
- Volume :
- 188
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of experimental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 9653089
- Full Text :
- https://doi.org/10.1084/jem.188.1.119