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1-[2(R)-(2-amino-2-methylpropionylamino)-3-(1H-indol-3-yl)propionyl]- 3-benzylpiperidine-3(S)-carboxylic acid ethyl ester (L-163,540): a potent, orally bioavailable, and short-duration growth hormone secretagogue.
- Source :
-
Journal of medicinal chemistry [J Med Chem] 1998 Jul 02; Vol. 41 (14), pp. 2439-41. - Publication Year :
- 1998
- Subjects :
- Administration, Oral
Animals
Biological Availability
Crystallography, X-Ray
Dogs
Esters administration & dosage
Esters pharmacokinetics
Esters pharmacology
Growth Hormone blood
In Vitro Techniques
Male
Piperidines administration & dosage
Piperidines pharmacokinetics
Piperidines pharmacology
Pituitary Gland cytology
Pituitary Gland drug effects
Pituitary Gland metabolism
Rats
Rats, Sprague-Dawley
Stereoisomerism
Esters chemical synthesis
Growth Hormone metabolism
Piperidines chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0022-2623
- Volume :
- 41
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 9651148
- Full Text :
- https://doi.org/10.1021/jm9800191