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Combined effects of simultaneous exposure to toluene and ethanol on auditory function in rats.
- Source :
-
Neurotoxicology and teratology [Neurotoxicol Teratol] 1998 May-Jun; Vol. 20 (3), pp. 321-32. - Publication Year :
- 1998
-
Abstract
- Three experimental groups and one control group of Long-Evans rats were used to study the combined effects of toluene and ethanol on auditory function. The first experimental group was exposed to toluene vapors (1750 ppm, 6 h/day, 5 days/week, 4 weeks), the second one was daily gavaged with a saline solution of ethanol (4 g/kg, 4 weeks), and the last group was simultaneously exposed to both toluene and ethanol. Auditory function was tested by recording brain stem (inferior colliculus) auditory-evoked potentials for audiometric frequencies ranging from 2 to 32 kHz. Urinary hippuric acid was dosed to check the toluene metabolism during the experiments. Ethanol clearly modified the toluene metabolism in the present experimental conditions. As a result, the hearing loss induced by a simultaneous exposure to both ethanol and toluene was larger than that induced by exposure to toluene alone.
Details
- Language :
- English
- ISSN :
- 0892-0362
- Volume :
- 20
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Neurotoxicology and teratology
- Publication Type :
- Academic Journal
- Accession number :
- 9638690
- Full Text :
- https://doi.org/10.1016/s0892-0362(97)00093-7