Back to Search
Start Over
Diminished monocytic HLA-DR expression and ex vivo cytokine secretion capacity in patients with glioblastoma: effect of tumor extirpation.
- Source :
-
Journal of neuroimmunology [J Neuroimmunol] 1998 Apr 15; Vol. 84 (2), pp. 164-71. - Publication Year :
- 1998
-
Abstract
- Severe immunodysregulation on lymphocyte level has been described in patients with glioblastoma and is likely involved into its unfavorable prognosis. Although the major importance of monocytic cells for immunoregulation is well established, only very limited data exist regarding the monocyte status in glioblastoma patients. Here we demonstrate a markedly diminished monocytic HLA-DR expression and ex vivo cytokine secretion capacity (TNF-alpha, IL-1beta, IL-10) as signs for monocyte deactivation in glioblastoma patients but not in patients with astrocytoma. As known in immunocompromised patients from other reasons, monocyte deactivation indicate global immunodepression associated with an enhanced risk of infectious complications. Interestingly, tumor resection resulted in partial recovery from the monocytic deactivation. This suggests that the glioblastoma itself contributed to this phenomenon. However, IL-10 and the active forms of transforming growth factor-beta2 and -beta1, which are produced by glioblastoma cells and known to inhibit monocyte function, were not detectable in plasma in our patients. Moreover, low levels of the adrenocorticotropic hormone and cortisol excluded hypothalamo-pituitary-adrenal axis involvement. So, further investigations are necessary to clarify the mechanism. The demonstrated severe glioblastoma-associated monocytic deactivation may contribute to its unfavorable prognosis. Therefore, monocytes may represent target cells for new adjuvant immunotherapies in glioblastoma.
- Subjects :
- Adrenocorticotropic Hormone blood
Adult
Aged
Endotoxins pharmacology
Female
HLA-DR Antigens biosynthesis
Humans
Hydrocortisone blood
Hypothalamo-Hypophyseal System immunology
Hypothalamo-Hypophyseal System metabolism
Interleukin-10 metabolism
Male
Middle Aged
Monocytes drug effects
Monocytes immunology
Pituitary-Adrenal System immunology
Pituitary-Adrenal System metabolism
Transforming Growth Factor beta metabolism
Tumor Necrosis Factor-alpha metabolism
Brain Neoplasms immunology
Cytokines metabolism
Glioblastoma immunology
HLA-DR Antigens metabolism
Monocytes metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0165-5728
- Volume :
- 84
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 9628459
- Full Text :
- https://doi.org/10.1016/s0165-5728(97)00236-1