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The effect of amiloride on the metastatic properties of prostate cancer in the Dunning rat model.
- Source :
-
Oncology reports [Oncol Rep] 1998 Jul-Aug; Vol. 5 (4), pp. 889-92. - Publication Year :
- 1998
-
Abstract
- Most deaths from cancer result from the metastatic spread of the disease. The antidiuretic amiloride has been shown to inhibit tumor growth and metastasis in several tumor systems. The object of these studies was to examine the effect on the in vitro and in vivo tumor growth and metastasis in the MatLyLu subline of the Dunning model of rat prostate cancer. In vitro, amiloride was found to have cytotoxic effects only at high concentrations, with an IC50 of 100 microg/ml. In vitro analysis of the ability of amiloride to inhibit invasion of MLL cells demonstrated that this drug was ineffective at all concentrations examined. In vivo, amiloride did not inhibit tumor growth or metastases development. Our studies demonstrate that amiloride does not have activity in this model of prostate cancer and suggest it may not be an appropriate therapy for the treatment of prostate cancer.
- Subjects :
- Animals
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Male
Neoplasm Invasiveness
Neoplasm Metastasis prevention & control
Prostatic Neoplasms pathology
Rats
Treatment Outcome
Tumor Cells, Cultured
Amiloride therapeutic use
Antineoplastic Agents therapeutic use
Prostatic Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1021-335X
- Volume :
- 5
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Oncology reports
- Publication Type :
- Academic Journal
- Accession number :
- 9625839
- Full Text :
- https://doi.org/10.3892/or.5.4.889