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[The complement-activating action of modern x-ray contrast agents].
- Source :
-
Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 1998 Mar-Apr; Vol. 61 (2), pp. 60-4. - Publication Year :
- 1998
-
Abstract
- The study conducted proved that triombrast (dose dependently) > hexabrics > Ultravist > or = melitrast = omnipac in a concentration interval of 0.03-30.0 mg iodine/ml in vitro and in a dose interval of 0.5-2.0 g iodine/kg in vivo activate the complement system (CS) according to the alternative way in the blood of "sensitive" rats. The degree of CS activation by radiopaque agents (ROA) is significantly determined mathematically by their viscosity and relation of the number of iodine atoms to the number of ions or dissolved particles, and by their hydrophilic (for nonion CS) and osmotic (for ion monomeric CS) properties.
- Subjects :
- Animals
Complement Hemolytic Activity Assay statistics & numerical data
Complement Pathway, Alternative drug effects
Contrast Media chemistry
Dose-Response Relationship, Drug
Female
In Vitro Techniques
Linear Models
Male
Random Allocation
Rats
Rats, Wistar
Complement Activation drug effects
Contrast Media pharmacology
Subjects
Details
- Language :
- Russian
- ISSN :
- 0869-2092
- Volume :
- 61
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Eksperimental'naia i klinicheskaia farmakologiia
- Publication Type :
- Academic Journal
- Accession number :
- 9621179