Back to Search
Start Over
Effects of SA6541, a leukotriene A4 hydrolase inhibitor, and indomethacin on carrageenan-induced murine dermatitis.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 1998 Apr 03; Vol. 346 (1), pp. 81-5. - Publication Year :
- 1998
-
Abstract
- We investigated the effects of S-(4-dimethylaminobenzyl)-N-[(2S)-3-mercapto-2-methylpropionyl]-L- cysteine (SA6541), a potent leukotriene A4 hydrolase inhibitor. on early phase of carrageenan-induced dermatitis model. Carrageenan injection induced edema and neutrophil influx in the mouse ear. SA6541 inhibited edema formation and neutrophil influx. SA6541 also inhibited leukotriene B4 production but not prostaglandin E2 production in the mouse ear. On the other hand, indomethacin inhibited edema formation but not neutrophil influx. Indomethacin also inhibited prostaglandin E2 production but not leukotriene B4 production. Combination therapy with SA6541 and indomethacin strongly inhibited edema formation in comparison with treatment with either agent alone. These results suggest that leukotriene B4 may be important in the pathogenesis of dermatitis.
- Subjects :
- Animals
Cysteine pharmacology
Dermatitis, Contact metabolism
Edema prevention & control
Leukotriene B4 antagonists & inhibitors
Leukotriene B4 biosynthesis
Male
Mice
Mice, Inbred ICR
Aniline Compounds pharmacology
Carrageenan toxicity
Cysteine analogs & derivatives
Dermatitis, Contact prevention & control
Enzyme Inhibitors pharmacology
Epoxide Hydrolases antagonists & inhibitors
Indomethacin pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2999
- Volume :
- 346
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 9617756
- Full Text :
- https://doi.org/10.1016/s0014-2999(98)00127-7