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Nuclear overexpression of bcl-2 oncoprotein during the progression of human stomach cancer.

Authors :
Lee SS
Cho KJ
Hong SI
Myoung NK
Jang JJ
Source :
Journal of Korean medical science [J Korean Med Sci] 1998 Apr; Vol. 13 (2), pp. 153-8.
Publication Year :
1998

Abstract

We unexpectedly observed strong nuclear overexpression of bcl-2 protein in advanced stomach cancer. As far as we know, such expression has not yet been reported. To investigate the significance of nuclear expression of bcl-2 protein in gastric carcinoma, we immunohistochemically analyzed bcl-2 overexpression in a gastric carcinogenic sequence, including 19 tubular adenomas (TA), 20 early carcinomas (EGC), and 20 advanced carcinomas (AGC). While TA displayed a specific granular and supranuclear cytoplasmic staining pattern, adenocarcinomas showed a strong nuclear staining pattern. Nuclear staining of bcl-2 was observed in 50% of AGC, 30% of EGC, and 10% of TA; cytoplasmic staining, on the other hand, was observed in all TA, 5% of EGC, and 10% of AGC. Nuclear bcl-2 overexpression differed according to the histologic type of AGC, occurring in 67% of the diffuse type and 25% of the moderately-to-well differentiated type. In the diffuse type, nuclear bcl-2 positive AGC predominated. In metastatic lesions, the pattern of bcl-2 immunostaining was almost identical to that seen in primary tumor. These results suggest that nuclear expression of bcl-2 may be related to malignant transformation in the stomach and is frequently associated with diffuse type advanced gastric adenocarcinomas.

Details

Language :
English
ISSN :
1011-8934
Volume :
13
Issue :
2
Database :
MEDLINE
Journal :
Journal of Korean medical science
Publication Type :
Academic Journal
Accession number :
9610615
Full Text :
https://doi.org/10.3346/jkms.1998.13.2.153