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Parental history of hypertension and parental history of diabetes and microvascular complications in insulin-dependent diabetes mellitus: the EURODIAB IDDM Complications Study.
- Source :
-
Diabetic medicine : a journal of the British Diabetic Association [Diabet Med] 1998 May; Vol. 15 (5), pp. 418-26. - Publication Year :
- 1998
-
Abstract
- Diabetic nephropathy clusters in families, suggesting an inherited predisposition. Parental history of hypertension and of Type 2 diabetes mellitus have been associated with nephropathy in offspring with Type 1 diabetes in some studies but not in others. The associations of parental history of hypertension and of diabetes with both albuminuria and proliferative retinopathy were studied in a large cross-sectional study of 3250 patients with Type 1 diabetes, from 16 European countries. Albuminuria was associated with hypertension in a parent (p < 0.01 in men, p < 0.05 in women), adjusted for age. Patients with a parental history of hypertension had a higher prevalence of hypertension (p < 0.001 in men, p < 0.01 in women) and a higher prevalence of parental diabetes (p < 0.001 in men, p < 0.001 in women). The association of albuminuria with parental hypertension was independent of parental diabetes in men but not women (OR = 1.28 in men p = 0.04, OR = 1.25 in women p = 0.09) and was not independent of hypertension in the patient him/herself in either sex. Albuminuria was associated with parental diabetes in women only (OR = 1.36, p = 0.04). This association was independent of both parental hypertension and hypertension in the patient herself. Proliferative retinopathy was not associated with parental hypertension or diabetes. The implications of these data are that both candidate genes for hypertension and Type 2 diabetes should be considered in the search for the genetic determinants of diabetic nephropathy.
- Subjects :
- Adolescent
Adult
Albuminuria complications
Albuminuria epidemiology
Albuminuria genetics
Cohort Studies
Cross-Sectional Studies
Diabetes Mellitus, Type 1 genetics
Diabetes Mellitus, Type 2 genetics
Diabetic Angiopathies genetics
Diabetic Nephropathies complications
Diabetic Nephropathies epidemiology
Diabetic Nephropathies genetics
Diabetic Retinopathy complications
Diabetic Retinopathy epidemiology
Diabetic Retinopathy genetics
Europe epidemiology
Family Health
Female
Humans
Hypertension genetics
Male
Microcirculation pathology
Middle Aged
Parents
Prevalence
Diabetes Mellitus, Type 1 complications
Diabetes Mellitus, Type 2 complications
Diabetic Angiopathies complications
Hypertension complications
Subjects
Details
- Language :
- English
- ISSN :
- 0742-3071
- Volume :
- 15
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Diabetic medicine : a journal of the British Diabetic Association
- Publication Type :
- Academic Journal
- Accession number :
- 9609365
- Full Text :
- https://doi.org/10.1002/(SICI)1096-9136(199805)15:5<418::AID-DIA604>3.0.CO;2-P