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[Acute diffuse interstitial pneumopathy following docetaxel (Taxotère). Apropos of 2 cases].
- Source :
-
Revue des maladies respiratoires [Rev Mal Respir] 1998 Apr; Vol. 15 (2), pp. 199-203. - Publication Year :
- 1998
-
Abstract
- Docetaxel, a new chemotherapeutic agent, has demonstrated activity in non-small cell lung cancer and breast cancer. Toxicities associated with treatment using docetaxel include hypersensitivity reactions and fluid retention, which can be prevented by pretreatment with corticosteroids. We describe herein two cases of acute interstitial pneumonitis after administration of docetaxel to patients suffering from metastatic non-small cell lung cancer. A pulmonary toxicity of docetaxel from an hypersensitivity reaction is likely because of symptoms course, radiological demonstration of an interstitial pneumonitis, lack of an infectious etiology and of clinical response to antibiotic treatment, and rapid recovery with corticosteroids. This unusual pulmonary toxicity has been rarely described with docetaxel, as transient pulmonary infiltrates have been observed during treatment with paclitaxel. The possibility of an hypersensitivity pneumonitis must be taken into account when a patient with docetaxel treatment presents pulmonary infiltrates.
- Subjects :
- Aged
Alveolitis, Extrinsic Allergic chemically induced
Alveolitis, Extrinsic Allergic drug therapy
Anti-Inflammatory Agents therapeutic use
Carcinoma, Non-Small-Cell Lung secondary
Docetaxel
Drug Hypersensitivity drug therapy
Drug Hypersensitivity etiology
Glucocorticoids therapeutic use
Humans
Lung drug effects
Lung Diseases, Interstitial drug therapy
Male
Paclitaxel adverse effects
Prednisolone therapeutic use
Pulmonary Edema chemically induced
Pulmonary Edema drug therapy
Antineoplastic Agents, Phytogenic adverse effects
Carcinoma, Non-Small-Cell Lung drug therapy
Lung Diseases, Interstitial chemically induced
Lung Neoplasms drug therapy
Paclitaxel analogs & derivatives
Taxoids
Subjects
Details
- Language :
- French
- ISSN :
- 0761-8425
- Volume :
- 15
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Revue des maladies respiratoires
- Publication Type :
- Academic Journal
- Accession number :
- 9608992