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The effects of equivalent doses of tromethamine or sodium bicarbonate in healthy horses.
- Source :
-
Veterinary surgery : VS [Vet Surg] 1998 May-Jun; Vol. 27 (3), pp. 284-91. - Publication Year :
- 1998
-
Abstract
- Objective: To describe the effects of tromethamine, a putative treatment for metabolic acidosis, and to compare its biochemical effects with those of sodium bicarbonate.<br />Design: Randomized intervention study with repeated measures.<br />Animals: 16 healthy horses, 3 to 17 years old, weighing 391 to 684 kg.<br />Methods: Ten horses received 3 mEq/kg tromethamine and six received 3 mEq/kg sodium bicarbonate. Samples of venous blood and cerebrospinal fluid (CSF) were collected at intervals before and after drug administration. Heart rate and breathing rate were also recorded at intervals.<br />Results: Median standard base excess increased significantly (P < .05) from baseline immediately after both bicarbonate and tromethamine. These increases were not significantly different between treatments. Standard base excess returned toward baseline but remained significantly increased 3 hours after infusion of either treatment. After tromethamine, there was a significant decrease in plasma sodium concentration that lasted for at least 90 minutes. After sodium bicarbonate, no change in plasma sodium concentration was detected. Both sodium bicarbonate and tromethamine increased carbon dioxide tension in venous blood and CSF. Despite venous alkalemia, the pH of CSF decreased after both treatments.<br />Conclusions: Tromethamine and sodium bicarbonate have similar alkalinizing ability. Tromethamine causes hyponatremia, whereas both tromethamine and sodium bicarbonate increase carbon dioxide tension in venous blood and CSF.<br />Clinical Relevance: If hyponatremia, hypercarbia, and acidosis of the CSF occur after tromethamine is given to horses with existing metabolic acidosis, some of the potential advantages of tromethamine may prove theoretical rather than practical.
- Subjects :
- Animals
Blood Proteins drug effects
Buffers
Carbon Dioxide blood
Carbon Dioxide cerebrospinal fluid
Chlorides blood
Chlorides cerebrospinal fluid
Female
Heart Rate drug effects
Hematocrit veterinary
Horses physiology
Hydrogen-Ion Concentration
Male
Oxygen blood
Oxygen cerebrospinal fluid
Respiration drug effects
Sodium blood
Acid-Base Equilibrium drug effects
Horses blood
Horses cerebrospinal fluid
Sodium Bicarbonate pharmacology
Tromethamine pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0161-3499
- Volume :
- 27
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Veterinary surgery : VS
- Publication Type :
- Academic Journal
- Accession number :
- 9605240
- Full Text :
- https://doi.org/10.1111/j.1532-950x.1998.tb00129.x