Back to Search
Start Over
Spontaneous congenital hydrocephalus in the mutant mouse hyh. Changes in the ventricular system and the subcommissural organ.
- Source :
-
Journal of neuropathology and experimental neurology [J Neuropathol Exp Neurol] 1998 Feb; Vol. 57 (2), pp. 188-202. - Publication Year :
- 1998
-
Abstract
- The subcommissural organ is an ependymal gland located at the entrance of the cerebral aqueduct. It secretes glycoproteins into the cerebrospinal fluid, where they aggregate to form Reissner's fiber. This fiber grows along the aqueduct, fourth ventricle, and central canal. There is evidence that the subcommissural organ is involved in the pathogenesis of congenital hydrocephalus. This organ was investigated in the mutant mouse hyh developing a congenital hydrocephalus. The central nervous system of normal and hydrocephalic hyh mice, 1 to 40 days old, was investigated using antibodies recognizing the subcommissural organ secretory glycoproteins, and by transmission and scanning electron microscopy. At birth, the affected mice displayed open communications between all ventricles, absence of a central canal in the spinal cord, ependymal denudation of the ventricles, stenosis of the rostral end of the aqueduct, and hydrocephalus of the lateral and third ventricles and of the caudal end of the aqueduct. Around the 5th postnatal day, the communication between the caudal aqueduct and fourth ventricle sealed, and hydrocephalus became severe. It is postulated that the hyh mice carry a genetic defect affecting the ependymal cell lineage. The subcommissural organ showed signs of increased secretory activity; it released to the stenosed aqueduct a material that aggregated, but it did not form a Reissner's fiber. A large area of the third ventricular wall differentiated into a secretory ependyma synthesizing a material similar to that secreted by the subcommissural organ. It is concluded that the subcommissural organ changes during hydrocephalus; whether these changes precede hydrocephalus needs to be investigated.
- Subjects :
- Aging
Alleles
Animals
Brain abnormalities
Brain ultrastructure
Cerebral Ventricles abnormalities
Cerebral Ventricles ultrastructure
Female
Glycoproteins analysis
Homozygote
Male
Mice
Mice, Inbred C57BL
Mice, Neurologic Mutants
Microscopy, Electron
Microscopy, Electron, Scanning
Nerve Fibers pathology
Nerve Fibers ultrastructure
Subcommissural Organ abnormalities
Subcommissural Organ ultrastructure
Brain pathology
Cerebral Ventricles pathology
Hydrocephalus genetics
Hydrocephalus pathology
Subcommissural Organ pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3069
- Volume :
- 57
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of neuropathology and experimental neurology
- Publication Type :
- Academic Journal
- Accession number :
- 9600211
- Full Text :
- https://doi.org/10.1097/00005072-199802000-00010