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Involvement of nitric oxide synthase in proteinuria associated with chronic renal disease in rats.
- Source :
-
Pharmacology [Pharmacology] 1998 May; Vol. 56 (5), pp. 257-61. - Publication Year :
- 1998
-
Abstract
- The present study demonstrates that the nitric oxide synthase inhibitor, aminoguanidine, can attenuate the proteinuria observed in a predominantly noninflammatory model of chronic renal disease in the rat. These data suggest that nitric oxide synthase may be involved in progressive renal disease.
- Subjects :
- Animals
Blood Pressure drug effects
Blood Urea Nitrogen
Creatinine blood
Enzyme Inhibitors
Guanidines pharmacology
Kidney Failure, Chronic chemically induced
Kidney Failure, Chronic urine
Male
Nephrectomy
Nitric Oxide Synthase antagonists & inhibitors
Rats
Rats, Sprague-Dawley
Kidney Failure, Chronic enzymology
Nitric Oxide Synthase metabolism
Proteinuria enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 0031-7012
- Volume :
- 56
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 9597693
- Full Text :
- https://doi.org/10.1159/000028206