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TNFB gene polymorphism in insulin-dependent diabetes mellitus: association with HLA-DR alleles.
- Source :
-
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics [Eur J Immunogenet] 1998 Feb; Vol. 25 (1), pp. 39-41. - Publication Year :
- 1998
-
Abstract
- A polymorphism of the TNF-beta gene can be detected by restriction digestion of a PCR product with NcoI. In this study we look at the risk associated with this polymorphism in a study of 69 insulin-dependent diabetes patients and 119 healthy controls. The risk was further characterized by comparison to the HLA type of the individual, since the TNF polymorphism is in linkage disequilibrium with HLA genes.
Details
- Language :
- English
- ISSN :
- 0960-7420
- Volume :
- 25
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics
- Publication Type :
- Academic Journal
- Accession number :
- 9587743
- Full Text :
- https://doi.org/10.1046/j.1365-2370.1998.00088.x